Summaries and Trends of Interventional Trials in 2008-2017


Summary: We were interested in examining how the characteristics of trials registered at have changed over time.

Details: We accessed the AACT database using SAS(R) v 9.4. Our analysis was restricted to interventional studies registered between 2008-2017. We classified trials according to Funding source (Industry/NIH/Other, derived from sponsor and collaborator fields), Phase, Intervention Type, Site Location (U.S. sites compared to sites in the rest of the world), and appointment of a Data Monitoring Committee. We also examined patterns in months from study start to completion, and in months from study completion to reporting of results at in selected subgroups of studies. In this version we examined completeness of a few of the new data elements (e.g., about inclusion of a US FDA regulated drug product). An example graph is displayed in the image file displayed above. The attached Excel file displays additional graphs. To create the Excel file we generated summary numbers from SAS, output them, and created the graphs in Excel. Graphs were also generated directly using SAS procedures and output to a PDF file (see code and output shared via GitHub).

Attachment:   graphs_interventional_trials_January232018.xlsx

Karen Chiswell

K. Chiswell, Duke Clinical Research Institute

Submitted: 2018-01-30 12:19:59

Return to Gallery