Data-Sharing: AACT-based Research Projects

Background

Since the AACT database was launched in 2010, dozens of researchers have used it to better understand the state of clinical trials. Investigators have used AACT to study 'results reporting trends' to determine how compliant the research community has been with federally mandated regulations. Others have used AACT to find out which conditions & interventions tend to receive the most attention, which appear to be neglected, and how specific types of trials are distributed geographically.

Several AACT-based investigations have produced datasets, such as curated sets of condition terms used to identify a particular subset of studies. Providing access to this analytic data allows others interested in similar topics, or those who would like to further analyze or verify the investigations, to benefit and build upon the previous work.

Project Data Available in AACT

To facilitate public sharing of curated data resources between AACT users, we're making project datasets available within the AACT database. Each project has its own database schema that encapsulates the curated data the project's principal investigator has shared with us. Users of the live AACT database can query the project data and/or ClinicalTrials.gov data that resides in the main AACT schema: ctgov. They may join data across different schemas. In short, project information is kept structurally separate from ClinicalTrials.gov data, but the information is also integrated within the same database so it can be used in combination with current trial data.

The name of each project's database schema is identified in the table below. Click on the plus icon of any row in this table to view project details and access downloadable versions of the datasets and data definitions.

Name Investigators Organizations Publication Year Brief Summary DB Schema
CDEK’s Standard Organization Names Rebekah Griesenauer, PhD, Postdoctoral Scholar; Michael S Kinch, PhD, Associate Vice Chancellor Washington University - St. Louis. Center for Research Innovation and Biotechnology 2018 The CDEK project at Washington University has curated organization data to begin standardizing this terminology. Because an organization may be identified several different ways in ClinicalTrials.gov, it's often difficult to accurately identify all studies associated with an organization. Washington University has creating a queryable 'organization index' that provides a way for AACT users to more easily identify all studies associated with an organization. proj_cdek_standard_orgs
Characteristics of Clinical Trials Registered in ClinicalTrials.gov, 2007-2010 Robert M. Califf, MD; Deborah A. Zarin, MD; Judith M. Kramer, MD, MS; Rachel E. Sherman, MD, MPH; Laura H. Aberle, BSPH; Asba Tasneem, PhD Duke Clinical Research Institute 2012 The objective was to examine fundamental characteristics of interventional clinical trials registered in the ClinicalTrials.gov database. proj_tag_study_characteristics
Compliance with Results Reporting at ClinicalTrials.gov Monique L. Anderson, M.D., Karen Chiswell, Ph.D., Eric D. Peterson, M.D., M.P.H., Asba Tasneem, Ph.D., James Topping, M.S., and Robert M. Califf, M.D. Duke Clinical Research Institute 2015 Analysis of the levels & patterns of compliance with FDAAA reporting regulations for trials conducted between 2008 & 2013 (considering only those trials that are highly likely to be applicable to FDAAA provisions). proj_results_reporting
The Landscape of Clinical Trials in Nephrology: A Systematic Review of ClinicalTrials.gov Jula K. Inrig, MD,1,2 Robert M. Califf, MD,1 Asba Tasneem, PhD,1 Radha K. Vegunta, MD,3 Christopher Molina, BS,4 John W. Stanifer, MD,1 Karen Chiswell, PhD,1 and Uptal D. Patel, MD1 Duke Clinical Research Institute 2014 While conducting a systematic review of nephrology-related studies in ClinicalTrials.gov, the investigators tagged nephrology-related MeSH & free-text condition terms. Interventional studies registered between Oct 1, 2007 & September 27, 2010 with conditions, browse_conditions or keywords that matched any of the terms tagged as 'nephrology' were reviewed by investigators, to create the final subset of studies included in the analysis. proj_tag_nephrology

Please Note...

  • Project data are available in the live AACT database hosted at aact-db.ctti-clinicaltrials.org. Static copies of the database and pipe-delimited filesets available for download contain only ClinicalTrials.gov data; they do not include project information.

  • Files containing data element definitions (defining project-specific tables & columns) are available for download for some projects in the 'Other Attachments' section.

  • Currently, AACT includes analytic information for four AACT-based projects that CTTI determined will likely benefit the largest audience. Many other investigators have analyzed ClinicalTrials.gov data. CTTI intends to continue to add curated & analytic data from past and future research to further enhance this resource.

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